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Diindolylmethane (DIM) or 3,3′-Diindolylmethane is a compound derived from indole-3-carbinol, which is found in cruciferous vegetables such as broccoli, brussel sprouts, cabbage and kale. Dietary consumption of cruciferous vegetables has been observed to have positive impacts on various health parameters, detoxification, and disease conditions.* DIM may be one of the compounds that contributes to these benefits, as it has been shown to support a healthy immune response, normal hormone metabolism, and natural detoxification pathways.* DIM has been shown to be a strong inducer of the antioxidant response element (ARE), a regulator of the expression of many phase II drug metabolizing enzymes and phase III transporters.* When taken in traditional oral formulations, DIM has poor absorption and relatively rapid clearance. Lipid-based formulations have been shown to improve bioavailability. Absorption of nanoemulsified DIM significantly surpasses other oral-based therapies such as tablets and capsules as DIM, complexed with phospholipids, absorbs orally and enters lymphatic circulation.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Learn More
This blend of vitamin C (as sodium ascorbate) with R-lipoic acid (as sodium R-lipoate) simultaneously supports the body’s antioxidant status while supporting endogenous production of glutathione.* As an antioxidant, vitamin C scavenges and neutralizes free radicals, inhibits lipid peroxidation of cellular membranes, and supports levels of the other necessary antioxidants vitamin E and glutathione.* Beyond its role as an antioxidant, vitamin C supports normal immune system function, cholesterol metabolism, and the growth and repair of collagen. It also is a cofactor in numerous enzymatic reactions, and is necessary for the synthesis of hormones and neurotransmitters.* Lipoic acid has been shown to extend the biological activity of vitamins C and E, also raising ubiquinol (commonly known as CoQ10) levels and endogenous production of glutathione via the Nrf2 nuclear transcription pathway.* Lipoic acid is able to cross the blood-brain barrier and it has been shown to have neuroprotective effects.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Learn More
GABA (gamma-aminobutyric acid) is produced by neurons in the brain, and functions as the principle inhibitory neurotransmitter. GABA is associated with the parasympathetic side of the autonomic nervous system, which balances the sympathetic (fight-or-flight) response. Lower concentrations of GABA have been observed in major depression and post-traumatic stress disorder in the brain, and a region of the brain known as the insular cortex that is associated with emotional response.* Lower insula levels of GABA are associated with significantly higher trait and state anxiety.* GABA, as an inhibitory neurotransmitter, is one of the mediators responsible for reducing the response to fear or anxiety-provoking stimuli.* L-theanine is an amino acid found at high amounts in green tea. L-theanine supports relaxation and mood by increasing alpha-wave activity, and levels of serotonin, dopamine, and GABA in the brain.* L-theanine also has been shown to block binding of L-glutamic acid to excitatory glutamate receptors in the brain.* Glutamate receptor subtypes have been shown to modulate excitability associated with anxiety, while in depression, a hyperfunctioning glutaminergic system also may be an issue.* Continuous administration of L-theanine has been shown to increase expression of brain-derived neurotrophic factor (BDNF) protein, a protein which plays a role in neural plasticity and neurogenesis.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Learn More
Phosphatidylcholine (PC) is a vital component of the cellular membranes of plant and animal cells, necessary for membrane integrity, structure, and function. PC also is a normal constituent of bile and facilitates fat emulsification, absorption, and transport. Choline, provided by PC, is a precursor for the synthesis of acetylcholine, an important neurotransmitter centrally in the brain, and necessary peripherally for muscle control and other aspects of cholinergic signalling. Choline is considered an essential nutrient and must be obtained from the diet.* Although thresholds have been established for adequate intake of choline, studies have shown that this may not be sufficient for prevention of symptoms of choline deficiency such as fatty liver or muscle damage.* The risk of choline deficiency is higher in men, postmenopausal women, vegans or vegetarians, and individuals with genetic polymorphisms related to folate or choline metabolism. Sufficient levels of PC and choline are also necessary for homocysteine metabolism, fetal development, neurocognitive health, and liver detoxification of chemicals, heavy metals, and xenobiotics.* Choline supports the body’s antioxidant status, reducing lipid peroxidation, and is also a major source of methyl groups via its metabolite trimethylglycine (TMG), which is important for Phase II hepatic detoxification.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Learn More
Vitamin B12 is an essential water-soluble nutrient, necessary for DNA synthesis, red blood cell production, and neurological function. Vitamin B12 plays an important role in mood and memory, bone health, and fetal development.* Vitamin B12 is a necessary cofactor for the metabolism of homocysteine into methionine, and the subsequent formation of the universal methyl donor S-adenosylmethionine (SAMe) from methionine. Research has shown that many people can have difficulties metabolizing and absorbing vitamin B12, especially when digestive and/or intestinal functioning is suboptimal. Vitamin B12 deficiency is more common with age, hypochlorhydria, small intestinal bacterial overgrowth (SIBO), gastrointestinal bypass surgery, alcohol use, a vegetarian or vegan diet, and use of medications such as proton-pump inhibitors, metformin, and hormonal contraceptives. Genetic polymorphisms also may impact the availability of some forms of vitamin B12 to meet the body’s needs.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Learn More
B complex vitamins are critical for many processes inherent to life. They serve as cofactors for enzymatic reactions, and are necessary for gene expression, oxidation-reduction reactions, energy production, detoxification, and formation of other biologically essential compounds. All the B vitamins play a role in mitochondrial function, and deficiencies may be associated with oxidative stress and mitochondrial damage.* Although many of the B vitamins are present in the diet particularly in an era of “food fortification,” a large portion of the population still experiences deficiencies, particularly of B6, B12, and folate. Deficiencies may be attributable to age, hypochlorhydria, small intestinal bacterial overgrowth, alcohol use, poor nutritional intake, and use of medications such as proton-pump inhibitors, diuretics, metformin, and hormonal contraceptives. Genetic polymorphisms also may impact the ability of specific forms of B vitamins (e.g. folic acid used in food fortification and in cheap vitamin supplements) to meet the body’s needs.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Learn More
Clear Way Cofactors is a proprietary blend of botanically-sourced polyphenolic antioxidants, R-Lipoic Acid (RLA), targeted vitamins (B1, B5, B6), selenium, kelp extract (bladderwrack) and high-potency nattokinase designed to maximize metal detoxification pathways.* These polyphenolics and RLA have demonstrated the ability to upregulate the detoxification systems of the body, especially the glutathione system.* The glutathione system contains multiple molecules and enzymes that function to quench oxidative stress, repair damaged proteins and detoxify or remove endogenous (internally created) and exogenous (externally acquired) toxins. The optimal way to support the function of the glutathione system is to stimulate the production of the system components from within the cells.* Polyphenolic antioxidants such as epicatechin (found in pine bark extract), have demonstrated tremendous efficacy in doing this by "turning on" Nrf2, the master intracellular antioxidant switch.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.Learn More